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Journal Article

Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice

MPS-Authors
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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Mack,  Volker
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Draft,  Ryan
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://www.nature.com/neuro/journal/v8/n3/pdf/nn1412.pdf
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https://dx.doi.org/10.1038/nn1412
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Citation

Schmitt, W. B., Sprengel, R., Mack, V., Draft, R., Seeburg, P. H., Deacon, R. M. J., et al. (2005). Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice. Nature Neuroscience, 8(3), 270-272. doi:10.1038/nn1412.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-C62C-3
Abstract
Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.