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Book Chapter

Optogenetic light crafting tools for the control of cardiac arrhythmias.

MPS-Authors
/persons/resource/persons188803

Richter,  Claudia
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Christoph,  Jan
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173583

Luther,  Stefan
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

External Resource

http://www.springerprotocols.com/Full/doi/10.1007/978-1-4939-3512-3_20?encCode=U0VOOjAyXzMtMjE1My05Mzk0LTEtODc5&tokenString=wnMQZmZGxWPxfVFKDGkNtQ==
(Publisher version)

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Citation

Richter, C., Christoph, J., Lehnart, S. E., & Luther, S. (2016). Optogenetic light crafting tools for the control of cardiac arrhythmias. In A. Kianianmomeni (Ed.), Optogenetics: Methods and protocols. (pp. 293-302). New York, N.Y.: Springer. doi:10.1007/978-1-4939-3512-3.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-DA8B-9
Abstract
The control of spatiotemporal dynamics in biological systems is a fundamental problem in nonlinear sciences and has important applications in engineering and medicine. Optogenetic tools combined with advanced optical technologies provide unique opportunities to develop and validate novel approaches to control spatiotemporal complexity in neuronal and cardiac systems. Understanding of the mechanisms and instabilities underlying the onset, perpetuation, and control of cardiac arrhythmias will enable the development and translation of novel therapeutic approaches. Here we describe in detail the preparation and optical mapping of transgenic channelrhodopsin-2 (ChR2) mouse hearts, cardiac cell cultures, and the optical setup for photostimulation using digital light processing.