Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune 
blistering disease

Gupta, Yask; Möller, Steffen; Witte, Mareike; Belheouane, Meriem; Sezin, Tanya; Hirose, Misa; Vorobyev, Artem; Niesar, Felix; Bischof, Julia; Ludwig, Ralf J; Zillikens, Detlef; Sadik, Christian D; Restle, Tobias; Häsler, Robert; Baines, John F.; Ibrahim, Saleh M

doi:10.1186/s12864-016-2455-2

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Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease

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Belheouane, Meriem
Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Baines, John F.
Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Gupta, Y., Möller, S., Witte, M., Belheouane, M., Sezin, T., Hirose, M., et al. (2016). Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease. BMC Genomics, 17(1), 1-14. doi:10.1186/s12864-016-2455-2.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-84B0-B

Abstract

MicroRNAs (miRNAs) are small endogenous non-coding RNAs that control genes at post-transcriptional level. They are essential for development and tissue differentiation, and such altered miRNA expression patterns are linked to the pathogenesis of inflammation and cancer. There is evidence that miRNA expression is genetically controlled similar to the transcription of protein-coding genes and previous studies identified quantitative trait loci (QTL) for miRNA expression in the liver. So far, little attention has been paid to miRNA expression in the skin. Moreover, epistatic control of miRNA expression remains unknown. In this study, we characterize genetic regulation of cutaneous miRNA and their correlation with skin inflammation using a previously established murine autoimmune-prone advanced intercross line.