English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

The Brain as Immunoprecipitator of Serum Autoantibodies Against N-Methyl-D-Aspartate Receptor Subunit NR1

MPS-Authors
/persons/resource/persons80563

Uhr,  Manfred
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80515

Schmidt,  Ulrike
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80578

Weber,  Frank
Max Planck Institute of Psychiatry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Castillo-Gomez, E., Kaestner, A., Steiner, J., Schneider, A., Hettling, B., Poggi, G., et al. (2016). The Brain as Immunoprecipitator of Serum Autoantibodies Against N-Methyl-D-Aspartate Receptor Subunit NR1. ANNALS OF NEUROLOGY, 79(1), 144-151. doi:10.1002/ana.24545.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-11B1-B
Abstract
Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood-brain barrier (BBB). However, it remained unknown whether circulating NMDAR1 AB appear in the cerebrospinal fluid (CSF). Of n5271 subjects with CSF-serum pairs, 26 were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise, tetanus AB (non-brain-binding) were present in serum and CSF of all subjects, with CSF levels higher upon BBB dysfunction. Translational mouse experiments proved the hypothesis that the brain acts as an 'immunoprecipitator'; simultaneous injection of NMDAR1 AB and the non-brain-binding green fluorescent protein AB resulted in high detectability of the former in brain and the latter in CSF.