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The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development, and Chronic Physical Aggression: Prospects for Early Protective Interventions

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Provencal,  Nadine
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Tremblay, R. E., Booij, L., Provencal, N., & Szyf, M. (2016). The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development, and Chronic Physical Aggression: Prospects for Early Protective Interventions. TRANSLATIONAL TOXICOLOGY: DEFINING A NEW THERAPEUTIC DISCIPLINE, 295-319. doi:10.1007/978-3-319-27449-2_10.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-0C3F-4
Abstract
There is now convincing evidence from prospective and retrospective epidemiological studies that prenatal and early post-natal stressors have long term impacts on life span health and well-being. Unraveling the mechanisms by which early environmental stressors have an impact on DNA methylation and neurobehavioral development should provide the foundation for creating effective early protective interventions. We review the recent convergence of four research domains to explain the mechanisms leading to chronic physical aggression (behavior development, epigenetics, serotonin neurotransmission and immunology) and we discuss the next generation of studies that are needed to identify effective pre and post natal preventive interventions.