Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to 
acute regulation by the hypothalamic-pituitary-adrenocortical system?

Kellner, Michael; Wortmann, Viola; Salzwedel, Cornelie; Kober, Daniel; Petzoldt, Martin; Urbanowicz, Tatiana; Pulic, Mersija; Boelmans, Kai; Yassouridis, Alexander; Wiedemann, Klaus

doi:10.1016/j.psychres.2016.03.033

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Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system?

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Yassouridis, Alexander
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Kellner, M., Wortmann, V., Salzwedel, C., Kober, D., Petzoldt, M., Urbanowicz, T., et al. (2016). Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system? PSYCHIATRY RESEARCH, 239, 222-225. doi:10.1016/j.psychres.2016.03.033.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-7846-5

Abstract

Acute regulation of adrenocorticotropic hormone (ACTH) in cerebrospinal fluid (CSF) by the hypothalamic-pituitary-adrenocortical system has not been investigated in man. In a pilot study in healthy male volunteers we measured ACTH every twenty minutes in serial CSF for three hours after an intravenous placebo, hydrocortisone (100 mg) or insulin (2 mg/kg) injection. No acute inhibitory or stimulatory effects of these interventions were discovered. Our results corroborate previous findings in rhesus monkeys. The regulation of CSF ACTH and its potential relevance for behavioral alterations in health and disease (e.g. major depression or anorexia nervosa) in humans need further study. (C) 2016 Elsevier Ireland Ltd. All rights reserved.