English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Editorial Perspective: Psychological stress and epigenetic aging - what can we learn and how can we prevent?

MPS-Authors
/persons/resource/persons160236

Zannas,  Anthony S.
Max Planck Institute of Psychiatry, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Zannas, A. S. (2016). Editorial Perspective: Psychological stress and epigenetic aging - what can we learn and how can we prevent? Journal of child psychology and psychiatry, and allied disciplines, 57(6), 674-5. doi:10.1111/jcpp.12535.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-72DA-D
Abstract
Psychological stress can exert a lasting impact on the aging process. This hypothesis, long posited by Hans Selye, has been supported by evidence linking stressors with several aging-related disease phenotypes. However, little is known about the molecular mechanisms underlying this association. Among plausible mechanisms linking stress and aging, evidence supports the role of epigenetic modifications, a set of molecular processes that can be induced by environmental stressors and regulate gene expression without altering the underlying genetic sequence. In particular, recent evidence shows that psychological stress can accelerate epigenetic aging, a measure based on DNA methylation prediction of chronological age that shows promise as biomarker of aging. Some studies further suggest that epigenetic aging could be modifiable, albeit others contradict this hypothesis. Future studies will need to determine the preventability or reversibility of epigenetic aging in response to distinct interventions and the potential clinical implications of such a prevention or reversal.