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Journal Article

Cilia-based flow network in the brain ventricles.

MPS-Authors
/persons/resource/persons127439

Faubel,  R.
Department of Genes and Behavior, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons173707

Westendorf,  C.
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173472

Bodenschatz,  E.
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons15030

Eichele,  G.
Department of Genes and Behavior, MPI for Biophysical Chemistry, Max Planck Society;

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(Supplementary material), 8MB

2310535_Suppl_4.mp4
(Supplementary material), 11MB

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(Supplementary material), 10MB

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(Supplementary material), 22MB

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(Supplementary material), 16MB

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(Supplementary material), 17MB

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(Supplementary material), 7MB

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(Supplementary material), 10MB

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(Supplementary material), 17MB

Citation

Faubel, R., Westendorf, C., Bodenschatz, E., & Eichele, G. (2016). Cilia-based flow network in the brain ventricles. Science, 353(6295), 176-178. doi:10.1126/science.aae0450.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-FF74-F
Abstract
Cerebrospinal fluid conveys many physiologically important signaling factors through the ventricular cavities of the brain. We investigated the transport of cerebrospinal fluid in the third ventricle of the mouse brain and discovered a highly organized pattern of cilia modules, which collectively give rise to a network of fluid flows that allows for precise transport within this ventricle. We also discovered a cilia-based switch that reliably and periodically alters the flow pattern so as to create a dynamic subdivision that may control substance distribution in the third ventricle. Complex flow patterns were also present in the third ventricles of rats and pigs. Our work suggests that ciliated epithelia can generate and maintain complex, spatiotemporally regulated flow networks.