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Three-dimensional echo-planar cine imaging of cerebral blood supply using arterial spin labeling

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Shrestha,  Manoj
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Mildner,  Toralf
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Schlumm,  Torsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Shrestha_2016.pdf
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Citation

Shrestha, M., Mildner, T., Schlumm, T., Robertson, S. H., & Möller, H. E. (2016). Three-dimensional echo-planar cine imaging of cerebral blood supply using arterial spin labeling. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(6), 799-810. doi:10.1007/s10334-016-0565-0.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-1700-2
Abstract
Objective Echo-planar imaging (EPI) with CYlindrical Center-out spatiaL Encoding (EPICYCLE) is introduced as a novel hybrid three-dimensional (3D) EPI technique. Its suitability for the tracking of a short bolus created by pseudo-continuous arterial spin labeling (pCASL) through the cerebral vasculature is demonstrated. Materials and methods EPICYCLE acquires two-dimensional planes of k-space along center-out trajectories. These “spokes” are rotated from shot to shot about a common axis to encode a k-space cylinder. To track a bolus of labeled blood, the same subset of evenly distributed spokes is acquired in a cine fashion after a short period of pCASL. This process is repeated for all subsets to fill the whole 3D k-space of each time frame. Results The passage of short pCASL boluses through the vasculature of a 3D imaging slab was successfully imaged using EPICYCLE. By choosing suitable sequence parameters, the impact of slab excitation on the bolus shape could be minimized. Parametric maps of signal amplitude, transit time, and bolus width reflected typical features of blood transport in large vessels. Conclusion The EPICYCLE technique was successfully applied to track a short bolus of labeled arterial blood during its passage through the cerebral vasculature.