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Journal Article

Combined PET/MRI: Multimodality insights into acute stroke hemodynamics

MPS-Authors
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Mildner,  Toralf
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller,  Harald E.       
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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https://n.neurology.org/content/86/20/1926
(Publisher version)

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Citation

Werner, P., Saur, D., Mildner, T., Möller, H. E., Classen, J., Sabri, O., et al. (2016). Combined PET/MRI: Multimodality insights into acute stroke hemodynamics. Neurology, 86(20), 1926-1927. doi:10.1212/WNL.0000000000002682.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-1782-F
Abstract
A 61-year-old man underwent simultaneous PET/MRI 5.5 hours after sudden onset of aphasia (NIH Stroke Scale 4), which revealed a diffusion/perfusion mismatch of different extents as measured with pulsed arterial spin-labeling MRI (59 mL), perfusion-weighted MRI (27 mL), and [15O]H2O-PET (36 mL) (figure). Due to spontaneous recanalization, the penumbra tissue did not progress towards infarction. This demonstrates that the outcome of critically hypoperfused stroke brain tissue may be favorable even without sufficient collateral flow and without therapeutic intervention.1 Here, PET/MRI offers the chance to cross-evaluate MRI-based blood flow estimates against simultaneous PET in acute stroke, which may improve the understanding of stroke pathophysiology.