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Investigation of the influence of the extracellular matrix on water diffusion in brain and cartilage

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Georgi,  Jakob
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Metere,  Riccardo
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Georgi, J., Metere, R., Morawski, M., Jäger, C., & Möller, H. E. (2016). Investigation of the influence of the extracellular matrix on water diffusion in brain and cartilage. Talk presented at 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Singapore. 2016-05-07 - 2016-05-13.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-1D28-D
Abstract
Water diffusivity in biological tissues can be related to the underlying microstructure that modulates the restricted or hindered diffusion, and can be studied with NMR experiments. The extracellular matrix, whose composition depends on the tissue type, may have an influence on diffusion. In this work we study the influence of the extracellular matrix on diffusion, by measuring brain and cartilage samples before and after the enzymatic removal of the extracellular matrix components. The activation energy for the self-diffusion of water seems to be not significantly affected by the treatment for brain tissues.