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Alkyl Aryl Ether Bond Formation with PhenoFluor

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Citation

Shen, X., Neumann, C. N., Kleinlein, C., Goldberg, N. W., & Ritter, T. (2015). Alkyl Aryl Ether Bond Formation with PhenoFluor. Angewandte Chemie International Edition, 54(19), 5662-5665. doi:10.1002/anie.201500902.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-84B8-C
Abstract
An alkyl aryl ether bond formation reaction between phenols and primary and secondary alcohols with PhenoFluor has been developed. The reaction features a broad substrate scope and tolerates many functional groups, and substrates that are challenging for more conventional ether bond forming processes may be coupled. A preliminary mechanistic study indicates reactivity distinct from conventional ether bond formation.