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Comparison of single-shot rapid acquisition with relaxation enhancement and echo planar current density MRI sequences for monitoring of electric pulse delivery in irreversible electroporation

MPG-Autoren
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Trampel,  Robert
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zitation

Serša, I., Bajd, F., Kranjc, M., Busse, H., Garnov, N., Trampel, R., et al. (2016). Comparison of single-shot rapid acquisition with relaxation enhancement and echo planar current density MRI sequences for monitoring of electric pulse delivery in irreversible electroporation. In T. Jarm, & P. Kramar (Eds.), 1st World congress on electroporation and pulsed electric fields in biology, medicine and food & environmental technologies (pp. 83-86). Singapore: Springer.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-002B-2209-8
Zusammenfassung
Success of electroporation treatment critically depends on coverage of the target tissue with electric field. The electric field during delivery of the electroporation pulses can be reconstructed by the magnetic resonance electric impedance tomography, a method that uses current density distribution data and electric potentials at the electrodes for reconstruction of electric field in the sample. In this study, two complementary MRI methods for current density imaging during delivery of irreversible electroporation pulses are presented. One of the methods is based on the single-shot rapid acquisition with relaxation enhancement while the other is based on the echo planar imaging MRI method. The methods were compared in terms of their sensitivity and susceptibility to image artifacts by experiments on a liver test sample that were performed on a 2.35 T small bore MRI scanner. In the experiments, a standard protocol for irreversible electroporation where 90 electric pulses of 100 μs, 3000 V are delivered at 1 Hz was performed. Results of the study confirmed that both methods have comparable sensitivity. The RARE-based method was found less susceptible to artifacts while the EPI-based method has lower SAR value and may therefore be a better candidate for use in clinics.