English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Uses, misuses, new uses and fundamental limitations of magnetic resonance imaging in cognitive science

MPS-Authors
/persons/resource/persons20055

Turner,  Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)

Turner_2016.pdf
(Publisher version), 817KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Turner, R. (2016). Uses, misuses, new uses and fundamental limitations of magnetic resonance imaging in cognitive science. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 371(1705): 20150349. doi:10.1098/rstb.2015.0349.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-2897-7
Abstract
When blood oxygenation level-dependent (BOLD) contrast functional magnetic resonance imaging (fMRI) was discovered in the early 1990s, it provoked an explosion of interest in exploring human cognition, using brain mapping techniques based on MRI. Standards for data acquisition and analysis were rapidly put in place, in order to assist comparison of results across laboratories. Recently, MRI data acquisition capabilities have improved dramatically, inviting a rethink of strategies for relating functional brain activity at the systems level with its neuronal substrates and functional connections. This paper reviews the established capabilities of BOLD contrast fMRI, the perceived weaknesses of major methods of analysis, and current results that may provide insights into improved brain modelling. These results have inspired the use of in vivo myeloarchitecture for localizing brain activity, individual subject analysis without spatial smoothing and mapping of changes in cerebral blood volume instead of BOLD activation changes. The apparent fundamental limitations of all methods based on nuclear magnetic resonance are also discussed. This article is part of the themed issue ‘Interpreting BOLD: a dialogue between cognitive and cellular neuroscience’