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Exploring substrate scope and stereoselectivity of P450 peroxygenase OleTJE in olefin-forming oxidative decarboxylation

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Wang,  Jianbo
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Lonsdale,  Richard
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Wang, J., Lonsdale, R., & Reetz, M. T. (2016). Exploring substrate scope and stereoselectivity of P450 peroxygenase OleTJE in olefin-forming oxidative decarboxylation. Chemical Communications, 52, 8131-8133. doi:10.1039/C6CC04345C.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-2E8F-F
Abstract
As recently reported, the olefin-forming oxidative decarboxylation of straight-chain C4–C22 carboxylic acids catalyzed by P450 peroxygenase OleTJE constitutes a mild alkene synthesis. The present study shows that structurally different carboxylic acids are also accepted, including those that generate di-substituted olefins. Exploratory mutational experiments lead to increased trans-selectivity.