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The MSL complex: juggling RNA-protein interaction for dosage compensation and beyond

MPS-Authors

Keller,  Claudia Isabelle
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Akhtar,  A.
Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Keller, C. I., & Akhtar, A. (2015). The MSL complex: juggling RNA-protein interaction for dosage compensation and beyond. Current Opinion in Genetics & Development, 31, 1-11. doi:10.1016/j.gde.2015.03.007.


Cite as: http://hdl.handle.net/someHandle/test/escidoc:902510
Abstract
The Male Specific Lethal (MSL) complex provides an exquisite example of an epigenetic modulator that is involved in chromosome-wide as well as individual gene regulation in flies and mammals. In this review, we discuss the recent advances in biochemical and structural understanding of the MSL complex modules and how they function in X chromosome regulation in flies. Moreover, we describe possible conserved and dosage compensation-independent functions of the MSL complex with a particular focus on mammalian systems.