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Towards a comprehensive picture of allo acceptor tRNA remolding in metazoan mitochondrial genomes

MPG-Autoren

Sahyoun,  Abdullah H.
Bioinformatics Group, Department of Computer Science, Leipzig University;
Interdisciplinary Center for Bioinformatics, Leipzig University;
Doctoral School of Science and Technology, AZM Center for Biotechnology Research, Lebanese University;
RNA Bioinformatics and High Throughput Analysis, Faculty of Mathematics and Computer Sicence, Friedrich Schiller University Jena;
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Zitation

Sahyoun, A. H., Hölzer, M., Jühling, F., Höner zu Siederdissen, C., Al-Arab, M., Tout, K., et al. (2015). Towards a comprehensive picture of allo acceptor tRNA remolding in metazoan mitochondrial genomes. Nucleic Acids Research (London), 43, 8044-8056. doi:doi: 10.1093/nar/gkv746.


Zitierlink: https://hdl.handle.net/someHandle/test/escidoc:902584
Zusammenfassung
Remolding of tRNAs is a well-documented process in mitochondrial genomes that changes the identity of a tRNA. It involves a duplication of a tRNA gene, a mutation that changes the anticodon and the loss of the ancestral tRNA gene. The net effect is a functional tRNA that is more closely related to tRNAs of a different alloacceptor family than to tRNAs with the same anticodon in related species. Beyond being of interest for understanding mitochondrial tRNA function and evolution, tRNA remolding events can lead to artifacts in the annotation of mitogenomes and thus in studies of mitogenomic evolution. Therefore, it is important to identify and catalog these events. Here we describe novel methods to detect tRNA remolding in large-scale data sets and apply them to survey tRNA remolding throughout animal evolution. We identify several novel remolding events in addition to the ones previously mentioned in the literature. A detailed analysis of these remoldings showed that many of them are derived from ancestral events.