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Direct Catalytic Synthesis of Unprotected 2‐Amino‐1‐Phenylethanols from Alkenes by Using Iron(II) Phthalocyanine

MPS-Authors

Legnani,  Luca
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Morandi,  Bill
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Legnani, L., & Morandi, B. (2016). Direct Catalytic Synthesis of Unprotected 2‐Amino‐1‐Phenylethanols from Alkenes by Using Iron(II) Phthalocyanine. Angewandte Chemie International Edition, 55, 2248-2251. doi:10.1002/anie.201507630.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-43E6-8
Abstract
Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products . Herein, we report that an exceptionally simple and inexpensive Fe II complex efficiently catalyze sthe direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity .This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.