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Conference Paper

Structure modeling of the acetylcholine receptor channel and related ligand gated channels


von Kitzing,  Eberhard
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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von Kitzing, E. (1995). Structure modeling of the acetylcholine receptor channel and related ligand gated channels. In A. Pullmann, & J. Jortner (Eds.), Modelling of Biomolecular Structures and Mechanisms: Proceedings of the Twenty-Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 23–26, 1994 (pp. 39-57). Dordrecht: Springer Netherlands.

Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-5E3F-9
In this model-building study a model for the pore of the acetylcholine receptor channel is proposed. The pore is formed by five α-helices of the M2 segment where three rings of hydrophilic side chains point into the channel lumen. This model is in agreement with most experimental data like photolabeling, drug affinity studies, single channel conductivity measurements and cryo electron microscopy known about this channel. This study predicts a strong coupling of the motion of the ions in the channel to that of the charged and highly hydrophilic amino acid side chains at the channel wall. Due to the negative net-charge in the pore more than a single cation may occupy the pore region. The resulting strong local electric fields make the commonly used constant field approximation obsolete for this type of ion channel.