English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Self-recognition and clonal selection: autoreactivity drives the generation of B cells

MPS-Authors
/persons/resource/persons191097

Herzog,  Sebastian
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons191135

Jumaa,  Hassan
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Herzog, S., & Jumaa, H. (2012). Self-recognition and clonal selection: autoreactivity drives the generation of B cells. Current Opinion in Immunology, 24, 166-172.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-8D50-A
Abstract
The diversity of B cell receptor (BCR) specificities is generated by VDJ recombination of gene segments during early B cell development, a process which bears the risk of producing BCRs that recognize and lead to the destruction of self-structures. Traditional thoughts have mainly focused on how such putatively dangerous specificities are dealt with and in how they contribute to the development of autoimmune diseases. However, a positive or even necessary role of self-recognition during B cell development has rarely been taken into account. Now, considerable data reveal that the pre-B cell receptor (pre-BCR), which marks an important checkpoint during B cell development, acts as a surrogate autoreactive receptor. This review outlines how autoreactivity is necessary for efficient B cell development and how autoreactive receptors drive positive selection, leading to a diverse repertoire of receptor specificities in the mature B cell pool.