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Interactions between subunits of the Mediator complex with gene-specific transcription factors

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Borggrefe,  Tilman
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Yue,  Xiaojing
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Borggrefe, T., & Yue, X. (2011). Interactions between subunits of the Mediator complex with gene-specific transcription factors. Seminars in Cell & Developmental Biology, 22, 759-768.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-8DF3-D
Abstract
The Mediator complex forms the bridge between gene-specific transcription factors and the RNA polymerase II (RNAP II) machinery. Mediator is a large polypetide complex consisting of about thirty polypeptides that are mostly conserved from yeast to human. Mediator coordinates RNAP II recruitment, phosphorylation of the C-terminal domain of RNAP II, enhancer-loop formation and post-initiation events. The focus of the review is to summarize the current knowledge of transcription factor/Mediator interactions in higher eukaryotes and illuminate the physiological and gene-selective roles of Mediator.