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Journal Article

Adenovirus-triggered innate signalling pathways

MPS-Authors
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Fejer,  G.
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Freudenberg,  M.
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Gyory,  I.
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Fejer, G., Freudenberg, M., Greber, U. F., & Gyory, I. (2011). Adenovirus-triggered innate signalling pathways. European Journal of Microbiology and Immunology, 4, 279-288.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-8E00-5
Abstract
Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the opitmal design of adenovirus vector application. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.