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Book Chapter

SUMO CONTROL

MPS-Authors

Maderböck,  Katharina
Max Planck Society;

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Pichler,  Andrea
Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Maderböck, K., & Pichler, A. (2010). SUMO CONTROL. In M. Groettrup, & Landes Bioscience (Eds.), Conjugation and Deconjugation of Ubiquitin Family Modifiers (pp. 158-169). USA: Landes Bioscience.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-8EC1-6
Abstract
Sumoylation, the covalent attachment of SUMO peptide to cellular proteins, is an essential regulator of protein function involved in a wide range of cellular events. Deregulation of the SUMO pathway is implicated in the pathogenesis of several diseases, so it is important to understand how this system is controlled. Sumoylation is a highly dynamic regulatory mechanism, involving an energy dependent enzyme cascade for conjugation and another set of enzymes for deconjugation. In this chapter we will highlight the different mechanisms controlling the SUMO system.