SUMO CONTROL

Maderböck, Katharina; Pichler, Andrea

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SUMO CONTROL

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Maderböck, Katharina
Max Planck Society;

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Pichler, Andrea
Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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引用

Maderböck, K., & Pichler, A. (2010). SUMO CONTROL. In M., Groettrup, & Landes Bioscience (Eds.), Conjugation and Deconjugation of Ubiquitin Family Modifiers (pp. 158-169). USA: Landes Bioscience.

引用: https://hdl.handle.net/11858/00-001M-0000-002B-8EC1-6

要旨

Sumoylation, the covalent attachment of SUMO peptide to cellular proteins, is an essential regulator of protein function involved in a wide range of cellular events. Deregulation of the SUMO pathway is implicated in the pathogenesis of several diseases, so it is important to understand how this system is controlled. Sumoylation is a highly dynamic regulatory mechanism, involving an energy dependent enzyme cascade for conjugation and another set of enzymes for deconjugation. In this chapter we will highlight the different mechanisms controlling the SUMO system.