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Identification of Starmaker-Like in Medaka as a Putative Target Gene of Pax2 in the Otic Vesicle

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Bajoghli,  Baubak
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Aghaallaei,  Marges
Max Planck Society;

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Citation

Bajoghli, B., Ramialison, M., Aghaallaei, M., Czerny, T., & Wittbrodt, J. (2009). Identification of Starmaker-Like in Medaka as a Putative Target Gene of Pax2 in the Otic Vesicle. Developmental Dynamics, 238, 2860-2866.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-8F4B-A
Abstract
Otoliths in bony fishes are involved in the function of the ear in the senses of balance and hearing. In a large-scale random in situ hybridization screen of genes expressed in the medaka developing ear, we identified starmaker-like (stm-l) gene, a novel homologue of zebrafish starmaker and human dentine sialo-phosphoprotein (dspp) gene. Despite the absence of sequence similarity between these genes, here we describe their similar genomic structure and expression patterns hinting for a conserved function. In medaka fry, stm-l is expressed in various organs such as otoliths, teeth, gills, and kidney. Additionally, our results provide evidence that stm-l is a putative downstream target gene of Pax2 transcription factor and Pax2 itself has a promoting function in otolith formation.