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Differential impact of L-Arginine deprivation on the activation and effector functions of T cells and macrophages

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Modolell,  M.
Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Müller,  I.
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Choi, B.-S., Clara Martinez-Falero, I., Corset, C., Munder, M., Modolell, M., Müller, I., et al. (2009). Differential impact of L-Arginine deprivation on the activation and effector functions of T cells and macrophages. Journal of Leukocyte Biology, 85, 268-277.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-8F54-3
Abstract
The metabolism of the amino acid L-arginine is emerging as a crucial mechanism for the regulation of immune responses. Here, we characterized the impact of L-arginine deprivation on T cell and macrophage (MΦ) effector functions: We show that whereas L-arginine is required unconditionally for T cell activation, MΦ can up-regulate activation markers and produce cytokines and chemokines in the absence of L-arginine. Furthermore, we show that L-arginine deprivation does not affect the capacity of activated MΦ to up-regulate L-arginine-metabolizing enzymes such as inducible NO synthase and arginase 1. Thus, our results show that to exert their effector functions, T cells and MΦ have different requirements for L-arginine.