Cutting Edge: Contact with Secondary Lymphoid Organs Drives Postthymic T Cell 
Maturation

Houston Jr., Evan G.; Nechanitzky, Robert; Fink, Pamela J.

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Cutting Edge: Contact with Secondary Lymphoid Organs Drives Postthymic T Cell Maturation

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Nechanitzky, Robert
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Houston Jr., E. G., Nechanitzky, R., & Fink, P. J. (2008). Cutting Edge: Contact with Secondary Lymphoid Organs Drives Postthymic T Cell Maturation. Journal of Immunology, 181, 5213-5217.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-909E-5

Abstract

T cell development, originally thought to be completed in the thymus, has recently been shown to continue for several weeks in the lymphoid periphery. The forces that drive this peripheral maturation are unclear. The use of mice transgenic for GFP driven by the RAG2 promoter has enabled the ready identification and analysis of recent thymic emigrants. Here, we show that recent thymic emigrant maturation is a progressive process and is promoted by T cell exit from the thymus. Further, we show that this maturation occurs within secondary lymphoid organs and does not require extensive lymphocyte recirculation.