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Journal Article

Evidence for a Functional Second Thymus in Mice

MPS-Authors
/persons/resource/persons190990

Bleul,  Conrad C.
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons190993

Boehm,  Thomas
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource

https://www.science.org/lookup/doi/10.1126/science.1123497
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Citation

Terszowski, G., Müller, S. M., Bleul, C. C., Blum, C., Schirmbeck, R., Reimann, J., et al. (2006). Evidence for a Functional Second Thymus in Mice. Science, 312, 284-287. doi:10.1126/science.1123497.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-925A-D
Abstract
The thymus organ supports the development of T cells and is located in the thorax. Here, we report the existence of a second thymus in the mouse neck, which develops after birth and grows to the size of a small lymph node. The cervical thymus had a typical medulla-cortex structure, was found to support T cell development, and could correct T cell deficiency in athymic nude mice upon transplantation. The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production.