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Co-evolution of a primordial peptide-presentation system and cellular immunity

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Boehm,  Thomas
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Boehm, T. (2006). Co-evolution of a primordial peptide-presentation system and cellular immunity. Nature Reviews Immunology, 6, 79-84.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-926A-9
Abstract
How did early vertebrates survive when their lymphocytes began to use antigen receptors with random specificities, despite their potential for extensive self-reactivity? Here, I propose that the quality-control mechanisms that tame self-reactivity in the adaptive immune system were derived, at least in part, from an ancient mechanism that guided sexual selection on the basis of evaluating genetic relatedness.