English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme

MPS-Authors
/persons/resource/persons191179

Kutejova,  Eva
Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons191042

Engist,  Bettina
Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Kanzler,  Benoît
Max Planck Society;

/persons/resource/persons190992

Bobola,  Nicoletta
Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Kutejova, E., Engist, B., Mallo, M., Kanzler, B., & Bobola, N. (2005). Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development, 132, 469-478.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-93C2-8
Abstract
The Hoxa2 transcription factor acts during development of the second branchial arch. As for most of the developmental processes controlled by Hox proteins, the mechanism by which Hoxa2 regulates the morphology of second branchial arch derivatives is unclear. We show that Six2, another transcription factor, is genetically downstream of Hoxa2. High levels of Six2 are observed in the Hoxa2 loss-of-function mutant. By using a transgenic approach to overexpress Six2 in the embryonic area controlled by Hoxa2, we observed a phenotype that is reminiscent of the Hoxa2 mutant phenotype. Furthermore, we demonstrate that Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region. These results strongly suggest that Six2 is a direct target of Hoxa2.