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Journal Article

MHC Class I Peptide as Chemosensory Signals in the Vomeronasal Organ

MPS-Authors
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Jäger,  Martina
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Boehm,  Thomas
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource

https://www.science.org/lookup/doi/10.1126/science.1102818
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Citation

Leinders-Zufall, T., Brennan, P., Widmayer, P., Chandramani S., P., Maul-Pavicic, A., Jäger, M., et al. (2004). MHC Class I Peptide as Chemosensory Signals in the Vomeronasal Organ. Science, 306, 1033-1037. doi:10.1126/science.1102818.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-9427-B
Abstract
The mammalian vomeronasal organ detects social information about gender, status, and individuality. The molecular cues carrying this information remain largely unknown. Here, we show that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gαo- and V2R receptor-express- ing zone of the vomeronasal epithelium. In behaving mice, the same peptides function as individuality signals underlying mate recognition in the context of pregnancy block. MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior.