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Journal Article

Instructive Role of Wnt/β-Catenin in Sensory Fate Specification in Neural Crest Stem Cells

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Brault,  Veronique
Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Kemler,  Rolf
Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Lee, H.-Y., Kleber, M., Hari, L., Brault, V., Suter, U., Taketo, M. M., et al. (2004). Instructive Role of Wnt/β-Catenin in Sensory Fate Specification in Neural Crest Stem Cells. Science, 303(5660), 1020-1023.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-943F-8
Abstract
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/β-catenin signal activation in emigrating neural crest stem cells (NCSCs) has little effect on the population size and instead regulates fate decisions. Sustained β-catenin activity in neural crest cells promotes the formation of sensory neural cells in vivo at the expense of virtually all other neural crest derivatives. Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a β-catenin-dependent manner. Thus, the role of Wnt/β-catenin in stem cells is cell-type dependent.