English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

MPS-Authors
/persons/resource/persons191147

Kemler,  Rolf
Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Cobas, M., Wilson, A., Ernst, B., Mancini, S. J. C., MacDonald, H. R., Kemler, R., et al. (2004). β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis. The Journal of Experimental Medicine, 199, 221-229.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-9466-0
Abstract
β-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the β-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is β-catenin independent. In contrast to earlier reports, these data exclude an essential role for β-catenin during hematopoiesis and lymphopoiesis.