β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

Cobas, Monica; Wilson, Anne; Ernst, Bettina; Mancini, Stéphane J. C.; MacDonald, H. Robson; Kemler, Rolf; Radtke, Freddy

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β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

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Kemler, Rolf
Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Cobas, M., Wilson, A., Ernst, B., Mancini, S. J. C., MacDonald, H. R., Kemler, R., et al. (2004). β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis. The Journal of Experimental Medicine, 199, 221-229.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-9466-0

Abstract

β-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the β-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is β-catenin independent. In contrast to earlier reports, these data exclude an essential role for β-catenin during hematopoiesis and lymphopoiesis.