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Journal Article

Systems biology of the 2-cell mouse embryo


Solter,  D.
Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Evsikov, A. V., de Vries, W. N., Peaston, A. E., Radford, E. E., Fancher, K. S., Chen, F. H., et al. (2004). Systems biology of the 2-cell mouse embryo. Cytogenetic and Genome Research, 105, 240-250.

Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-9472-3
The transcriptome of the 2-cell mouse embryo was analyzed to provide insight into the molecular networks at play during nuclear reprogramming and embryonic genome activation. Analysis of ESTs from a 2-cell cDNA library identified nearly 4,000 genes, over half of which have not been previously studied. Transcripts of mobile elements, especially those of LTR retrotransposons, are abundantly represented in 2-cell embryos, suggesting their possible role in introducing genomic variation, and epigenetic restructuring of the embryonic genome. Analysis of Gene Ontology of the 2-cell-stage expressed genes outlines the major biological processes that guide the oocyte-to-embryo transition. These results provide a foundation for understanding molecular control at the onset of mammalian development.