English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

LAT Links the Pre-BCR to Calcium Signaling

MPS-Authors
/persons/resource/persons191338

Su,  Yu-Wen
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons191135

Jumaa,  Hassan
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Su, Y.-W., & Jumaa, H. (2003). LAT Links the Pre-BCR to Calcium Signaling. Immunity, 19(2), 295-305.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-9512-2
Abstract
SLP-65-/- mice display a partial block at the pre-B cell stage of development. Here, we show that LAT is required for the differentiation of SLP-65-/- pre-B cells. We show that LAT and SLP-76 are recruited to the pre-BCR and associated with Ig-α upon pre-BCR engagement, whereas LAT interaction with SLP-76 is already detected in untreated pre-B cells. Reconstitution of LAT or SLP-65 expression in SLP-65/LAT-/- pre-B cells restored their calcium (Ca2+ mobilization capacity, led to downregulation of surface pre-BCR, and induced differentiation to BCR+ cells. Together, our results suggest that the adaptor proteins LAT and SLP-76 are involved in pre-BCR signaling, thereby rescuing arrested murine SLP-65-/- pre-B cells.