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Wnt3A Plays a Major Role in the Segmentation Clock Controlling Somitogenesis

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Aulehla,  Alexander
Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Wehrle,  Christian
Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Kemler,  Rolf
Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Kanzler,  Benoit
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Herrmann,  Bernhard G.
Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler, A., Kanzler, B., et al. (2003). Wnt3A Plays a Major Role in the Segmentation Clock Controlling Somitogenesis. Developmental Cell, 4(3), 395-406.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-955E-B
Abstract
The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/β-catenin signaling and the segmentation clock. Axin2, a negative regulator of the Wnt pathway, is directly controlled by Wnt/β-catenin and shows oscillating expression in the PSM, even when Notch signaling is impaired, alternating with Lfng expression. Moreover, Wnt3a is required for oscillating Notch signaling activity in the PSM. We propose that the segmentation clock is established by Wnt/β-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates.