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The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion

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Flemming,  Alexandra
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Brummer,  Tilman
Max Planck Society;

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Reth,  Michael
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Jumaa,  Hassan
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Flemming, A., Brummer, T., Reth, M., & Jumaa, H. (2003). The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nature Immunology, 4(1), 38-43.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-9588-B
Abstract
Mice deficient in the adaptor protein SLP-65 (also known as BLNK) have reduced numbers of mature B cells, but an increased pre-B cell compartment. We show here that compared to wild-type cells, SLP-65-/- pre-B cells show an enhanced ex vivo proliferative capacity. This proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In addition, SLP-65-/- mice have a high incidence of pre-B cell lymphoma. Reintroduction of SLP-65 into SLP-65-/- pre-B cells led to pre-BCR down-regulation and enhanced differentiation. Our results indicate that SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor.