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A Distinct Signaling Pathway used by the IgG-Containing B Cell Antigen Receptor

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Wakabayashi,  Chisato
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Adachi,  Takahiro
Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Wakabayashi, C., Adachi, T., Wienands, J., & Tsubata, T. (2002). A Distinct Signaling Pathway used by the IgG-Containing B Cell Antigen Receptor. Science, 298(5602), 2392-2395.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-95BF-F
Abstract
The immunoglobulin G (IgG)-containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal- transducing component, Igα/Igβ. Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22- mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens.