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Calcium permeability of ligand-gated channels

MPG-Autoren
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Burnashev,  Nail
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen

http://www.sciencedirect.com/science/article/pii/S0143416098900562/pdf?md5=3ac10a79cf36e02886b535c512f5072a&pid=1-s2.0-S0143416098900562-main.pdf
(beliebiger Volltext)

http://dx.doi.org/10.1016/S0143-4160(98)90056-2
(beliebiger Volltext)

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Zitation

Burnashev, N. (1998). Calcium permeability of ligand-gated channels. Cell Calcium, 24(5), 325-332. doi:10.1016/S0143-4160(98)90056-2.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002B-962D-2
Zusammenfassung
Ligand-gated channels activated by excitatory neurotransmitters: glutamate, acetylcholine, ATP or serotonin are cation channels permeable to Ca2+. Molecular cloning revealed a large variety of the ligand-gated channel subunits differentially expressed in mammalian brain. Many of them have different Ca2+ permeability providing immense diversity in Ca2+ entry mediated by ligand-gated channels during synaptic transmission. Functional analysis of cloned channels allowed to identify structural elements in the pore forming regions determining Ca2+ permeability for many types of ligand-gated channels. The functional role of the Ca2+ entry mediated by various ligand-gated channels in mammalian central nervous system is less understood. The studies reviewed in this article provide information about known structural determinants of Ca2+ permeability of the ligand-gated channels and the role of this particular pathway of Ca2+ entry in cell function.