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Journal Article

Bifidus factor. V. The activity of α- and β-methyl-N-acetyl-d-glucosaminides

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Kuhn,  Richard
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Rose, C. S., Kuhn, R., Zilliken, F., & Gyiirgy, P. (1945). Bifidus factor. V. The activity of α- and β-methyl-N-acetyl-d-glucosaminides. Archives of Biochemistry and Biophysics, 49(1), 123-129. doi:10.1016/0003-9861(54)90173-3.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-A680-1
Abstract
1. β-Methyl-N-acetyl-d-glucosaminide is a growth factor for Lactobacillus bifidus var. Penn. The corresponding α-glucoside is inactive. 2. When mixtures of the inactive α-methyl-N-acetyl-d-glucosaminide and of the active β-isomer are used, the activity of the β-isomer is enhanced up to fivefold. 3. Other compounds containing NH-CO groups did not enhance the activity of β-methyl-N-acetyl-d-glucosaminide. In general, no or only very slight enhancement by the α-glucoside was observed when the β-glucoside was replaced by other substances with bifidus factor activity. 4. Lactobacillus bifidus var. Penn contains an enzyme that hydrolyzes and inactivates β-methyl-N-acetyl-d-glucosaminide but not the corresponding α-glucoside. In the presence of the α-glucoside the rate of hydrolysis of the β-glucoside was decreased. The observed in vitro effect did not seem sufficient to explain the microbiological response.