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High-resolution myocardial T1 mapping using single-shot inversion-recovery fast low-angle shot MRI with radial undersampling and iterative reconstruction.

MPS-Authors
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Wang,  X.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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Joseph,  A. A.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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Kalentev,  O.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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Merboldt,  K. D.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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Voit,  D.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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Roeloffs,  V. B.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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van Zalk,  M.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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Frahm,  J.
Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society;

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2354767.pdf
(Publisher version), 3MB

Supplementary Material (public)

2354767-Suppl.avi
(Supplementary material), 546KB

Citation

Wang, X., Joseph, A. A., Kalentev, O., Merboldt, K. D., Voit, D., Roeloffs, V. B., et al. (2016). High-resolution myocardial T1 mapping using single-shot inversion-recovery fast low-angle shot MRI with radial undersampling and iterative reconstruction. British Journal of Radiology, 89(1068): 20160255. doi:10.1259/bjr.20160255.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-ACB4-1
Abstract
To develop a novel method for rapid myocardial T1 mapping at high spatial resolution. METHODS: The proposed strategy represents a single-shot inversion-recovery (IR) experiment triggered to early diastole during a brief breathhold. The measurement combines an adiabatic inversion pulse with a real-time readout by highly undersampled radial FLASH, iterative image reconstruction and T1 fitting with automatic deletion of systolic frames. The method was implemented on a 3 T MRI system using a GPU-equipped bypass computer for online application. Validations employed a T1 reference phantom including analyses at simulated heart rates from 40 to 100 bpm. In vivo applications involved myocardial T1 mapping in short-axis views of healthy young volunteers. RESULTS: At 1 mm in-plane resolution and 6 mm section thickness, the IR measurement could be shortened to 3 s without compromising T1 quantitation. Phantom studies demonstrated T1 accuracy and high precision for values ranging from 300 to 1500 ms and up to a heart rate of 100 bpm. Similar results were obtained in vivo yielding septal T1 values of 1246 ± 24 ms (base), 1256 ± 33 ms (mid-ventricular) and 1288 ± 30 ms (apex), respectively (mean ± SD, n=6). CONCLUSION: Diastolic myocardial T1 mapping with use of single-shot inversion-recovery FLASH offers high spatial resolution, T1 accuracy and precision, practical robustness and speed. Advances in knowledge: The proposed method will be beneficial for clinical applications relying on native and post-contrast T1 quantitation.