English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Book Chapter

Drosophila melanogaster as a model of muscle degeneration disorders.

MPS-Authors
/persons/resource/persons15827

Shcherbata,  H. R.
Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Kreipke, R. E., Kwon, Y. V., Shcherbata, H. R., & Ruohola-Baker, H. (2017). Drosophila melanogaster as a model of muscle degeneration disorders. In L. Pick (Ed.), Fly models of human diseases. (pp. 83-109). Cambridge, Mass.: Elsevier/Academic Pr. doi:10.1016/bs.ctdb.2016.07.003.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-AE93-C
Abstract
Drosophila melanogaster provides a powerful platform with which researchers can dissect complex genetic questions and biochemical pathways relevant to a vast array of human diseases and disorders. Of particular interest, much work has been done with flies to elucidate the molecular mechanisms underlying muscle degeneration diseases. The fly is particularly useful for modeling muscle degeneration disorders because there are no identified satellite muscle cells to repair adult muscle following injury. This allows for the identification of endogenous processes of muscle degeneration as discrete events, distinguishable from phenotypes due to the lack of stem cell-based regeneration. In this review, we will discuss the ways in which the fruit fly provides a powerful platform with which to study human muscle degeneration disorders.