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Journal Article

A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

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Stühmer,  W.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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2358730.pdf
(Publisher version), 409KB

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Citation

Noda, M., Suzuki, H., Numa, S., & Stühmer, W. (1989). A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II. FEBs Letters, 259(1), 213-216. doi:10.1016/0014-5793(89)81531-5.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-B78D-8
Abstract
A single point mutation of the rat sodium channel II reduces its sensitivity to tetrodotoxin and saxitoxin by more than three orders of magnitude. The mutation replaces glutamic acid 387 with a glutamine and has only slight effects on the macroscopic current properties, as measured under voltage-clamp in Xenopus oocytes injected with the corresponding cDNA-derived mRNA.