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Journal Article

Role of AMPA receptors in synaptic plasticity

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Sprengel, R. (2006). Role of AMPA receptors in synaptic plasticity. Cell and Tissue Research, 326(2), 447-455. doi:10.1007/s00441-006-0275-4.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-BD7D-F
Abstract
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system. The glutamate−mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR−A to GluR−D), post−transcriptional and post−translational modifications, the number of synaptic AMPA receptors, and auxiliary proteins. Functional AMPA receptors are located predominantly in the post−synapse but are also found at extra−synaptic sites and occasionally in the pre−synapse. Thus, many factors influence the tasks of AMPA receptors in neuronal signal transmission. At hippocampal synaptic connections, AMPA receptor functions have been well studied in vitro and in the mouse; however, it is unlikely that these observations can be generalized to all glutamatergic synapses in the brain