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Patent

Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis

MPS-Authors
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Seeberger,  Peter H.
Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons122050

Yang,  You
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121100

Chakkumkal,  Anish
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121765

Reinhardt,  Anika
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Fulltext (public)

2364340.pdf
(Publisher version), 8MB

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Abstract
The present invention relates to the total chemical synthesis of the monosaccharide 35# (R'-H), the disaccharide 36# (R'<>H; R''-H), the trisaccharide 37# (R'<>H; R''<>H; R'''<>H) and the tetrasaccharide 1# (R'<>H; R''<>H; R'''<>H) of the following general formula wherein R represents -Y-NH2Y represents a linker R' is H or R'' is H or R''' is H or of the lipopolysaccharide from Neisseria meningitidis, as well as to the trisaccharide 37# and the tetrasaccharide 1#, to vaccines containing at least one of the saccharides 1#, 35#, 36#, and 37# and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or the trisaccharide [alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.