Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  DetailsÜbersicht

Freigegeben
Patent

Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis

MPG-Autoren
/persons/resource/persons121849

Seeberger,  Peter H.
Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons122050

Yang,  You
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121100

Chakkumkal,  Anish
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121765

Reinhardt,  Anika
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)

2364340.pdf
(Verlagsversion), 8MB

Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Seeberger, P. H., Yang, Y., Chakkumkal, A., & Reinhardt, A.(2014). Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002C-03F3-0
Zusammenfassung
The present invention relates to the total chemical synthesis of the monosaccharide 35# (R'-H), the disaccharide 36# (R'<>H; R''-H), the trisaccharide 37# (R'<>H; R''<>H; R'''<>H) and the tetrasaccharide 1# (R'<>H; R''<>H; R'''<>H) of the following general formula wherein R represents -Y-NH2Y represents a linker R' is H or R'' is H or R''' is H or of the lipopolysaccharide from Neisseria meningitidis, as well as to the trisaccharide 37# and the tetrasaccharide 1#, to vaccines containing at least one of the saccharides 1#, 35#, 36#, and 37# and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or the trisaccharide [alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.