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Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns

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Broser,  Philip Julian
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Grinevich,  Valery
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Osten,  Pavel
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sakmann,  Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Haydon-Wallace,  Damian J.
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Broser, P. J., Grinevich, V., Osten, P., Sakmann, B., & Haydon-Wallace, D. J. (2008). Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns. Cerebral Cortex, 18(7), 1588-1603. doi:10.1093/cercor/bhm189.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-00F0-3
Abstract
We examined the effect of whisker trimming during early postnatal development on the morphology of axonal arbors in rat somatosensory cortex. Axonal arbors from populations of layer 2/3 pyramidal neurons in the D2 column were labeled by lentivirus-mediated expression of green fluorescent protein. Axonal projection patterns were compared between untrimmed control animals and animals with all whiskers in A-, B-, and C-rows trimmed (D- and E-rows left intact) from postnatal days 7 to 15 (termed from here on DE-pairing). Control animals had approximately symmetrical horizontal projections toward C- and E-row columns in both supra- and infragranular layers. Following DE-pairing, the density of axons in supragranular layers projecting from the labeled neurons in the D2 column was higher in E- than in C-row columns. This asymmetry resulted primarily from a reduction in projection density toward the deprived C-row columns. In contrast, no change was observed in infragranular layers. The results indicate that DE-pairing during early postnatal development results in reduced axonal projection from nondeprived into deprived columns and that cortical neurons are capable of structural rearrangements at subsets of their axonal arbors.