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Journal Article

The genomic basis of circadian and circalunar timing adaptations in a midge

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Vogel,  Heiko
Department of Entomology, Prof. D. G. Heckel, MPI for Chemical Ecology, Max Planck Society;

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Fulltext (public)

HEC355.pdf
(Publisher version), 8MB

Supplementary Material (public)

HEC355s1.pdf
(Supplementary material), 3MB

HEC355s2.zip
(Supplementary material), 21KB

HEC355s3.zip
(Supplementary material), 242KB

Citation

Kaiser, T. S., Poehn, B., Szkiba, D., Preussner, M., Sedlazeck, F. J., Zrim, A., et al. (2016). The genomic basis of circadian and circalunar timing adaptations in a midge. Nature, 540, 69-73. doi:10.1038/nature20151.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-0A07-0
Abstract
Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge whose reproduction is timed by circadian and circalunar clocks. Midges from different locations show strain-specific genetic timing adaptations. We examined genetic variation in five C. marinus strains from different locations and mapped quantitative trait loci for circalunar and circadian chronotypes. The region most strongly associated with circadian chronotypes generates strain-specific differences in the abundance of calcium/calmodulin-dependent kinase II.1 (CaMKII.1) splice variants. As equivalent variants were shown to alter CaMKII activity in Drosophila melanogaster, and C. marinus (Cma)-CaMKII.1 increases the transcriptional activity of the dimer of the circadian proteins Cma-CLOCK and Cma-CYCLE, we suggest that modulation of alternative splicing is a mechanism for natural adaptation in circadian timing.