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Towards unsupervised single-shot diffractive imaging of heterogeneous particles using X-ray free-electron.

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Rolles,  D.
Research Group of Structural Dynamics of (Bio)Chemical Systems, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Park, H. J., Loh, N. D., Sierra, R. G., Hampton, C. Y., Starodub, D., Martin, A. V., et al. (2013). Towards unsupervised single-shot diffractive imaging of heterogeneous particles using X-ray free-electron. Optics Express, 21(23), 28729-28742. doi:10.1364/OE.21.028729.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-0F01-5
Abstract
Single shot diffraction imaging experiments via X-ray free-electron lasers can generate as many as hundreds of thousands of diffraction patterns of scattering objects. Recovering the real space contrast of a scattering object from these patterns currently requires a reconstruction process with user guidance in a number of steps, introducing severe bottlenecks in data processing. We present a series of measures that replace user guidance with algorithms that reconstruct contrasts in an unsupervised fashion. We demonstrate the feasibility of automating the reconstruction process by generating hundreds of contrasts obtained from soot particle diffraction experiments.