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Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Inta, D., Trusel, M., Riva, M. A., Sprengel, R., & Gass, P. (2009). Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications. International Journal of Neuropsychopharmacology, 12(8), 1133-1136. doi:10.1017/S1461145709990319.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-115F-9
Abstract
Preclinical and clinical studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists can exert antidepressant effects. Thus, a single intravenous injection of ketamine, a non-competitive NMDA receptor antagonists, has been recently demonstrated to produce a rapid and relatively sustained antidepressant effect in patients. Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense research.