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Journal Article

Experimental Proof of Concept of Nanoparticle-Assisted STED


Foreman,  Matthew R.
Vollmer Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;

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Sonnefraud, Y., Sinclair, H. G., Sivan, Y., Foreman, M. R., Dunsby, C. W., Neil, M. A. A., et al. (2014). Experimental Proof of Concept of Nanoparticle-Assisted STED. NANO LETTERS, 14(8), 4449-4453. doi:10.1021/nl5014103.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-65CB-4
We imaged core-shell nanoparticles, consisting of a dye-doped silica core covered with a layer of gold, with a stimulated emission depletion, fluorescence lifetime imaging (STED-FLIM) microscope. Because of the field enhancement provided by the localized surface plasmon resonance of the gold shell, we demonstrate a reduction of the STED depletion power required to obtain resolution improvement by a factor of 4. This validates the concept of nanoparticle-assisted STED (NP-STED), where hybrid dye-plasmonic nanoparticles are used as labels for STED in order to decrease the depletion powers required for subwavelength imaging.