Measuring three-dimensional interaction potentials using optical interference

Mojarad, Nassir; Sandoghdar, Vahid; Krishnan, Madhavi

doi:10.1364/OE.21.009377

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Measuring three-dimensional interaction potentials using optical interference

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Sandoghdar, Vahid
Sandoghdar Division, Max Planck Institute for the Science of Light, Max Planck Society;

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Mojarad, N., Sandoghdar, V., & Krishnan, M. (2013). Measuring three-dimensional interaction potentials using optical interference. Optics Express, 21, 9377-9389. doi:10.1364/OE.21.009377.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-6785-0

Abstract

We describe the application of three-dimensional (3D) scattering interferometric (iSCAT) imaging to the measurement of spatial interaction potentials for nano-objects in solution. We study electrostatically trapped gold particles in a nanofluidic device and present details on axial particle localization in the presence of a strongly reflecting interface. Our results demonstrate high-speed (similar to kHz) particle tracking with subnanometer localization precision in the axial and average 2.5 nm in the lateral dimension. A comparison of the measured levitation heights of trapped particles with the calculated values for traps of various geometries reveals good agreement. Our work demonstrates that iSCAT imaging delivers label-free, high-speed and accurate 3D tracking of nano-objects conducive to probing weak and long-range interaction potentials in solution. (C) 2013 Optical Society of America